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Accelerating Innovations to Address Heavy Menstrual Bleeding in Women in Low-Resource Settings

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Heavy menstrual bleeding (HMB) affects millions of women globally. Clinically, HMB is defined as excessive menstrual blood loss that negatively affects a woman’s physical, emotional, and social well-being. In research settings, HMB is defined as directly measured blood loss exceeding 80 milliliters per menstrual cycle. Many women seek medical attention based on their perceptions of heavy bleeding and its impact on daily life. Abnormal uterine bleeding, of which HMB is a subset, is caused by various factors. Structural abnormalities include polyps, adenomyosis, fibroids, and malignancy, while non-structural factors include bleeding disorders, ovulatory and endometrial dysfunction, and other factors.

Managing HMB presents significant clinical challenges when diagnostic tools are unavailable or inaccessible to distinguish between the diverse possible etiologies. The underlying biological mechanisms, particularly related to endometrial dysfunction-related HMB also remain poorly understood. For an individual woman, the preferred medical and surgical treatment options depend on the specific cause, symptoms, preferences (including factors such as pregnancy intention), and the availability of treatment, including minimally invasive therapies. Currently available medical treatments include hormonal therapies, including contraceptives, such as the hormonal intrauterine device, and non-hormonal options, such as tranexamic acid and non-steroidal anti-inflammatory drugs (NSAIDs). The efficacy of treatment could be improved with an increased understanding of the underlying biological mechanisms and the development of specifically targeted therapies. 

Research priorities in HMB include understanding the underlying biological mechanisms, particularly related to endometrial dysfunction-related HMB, developing and introducing cost-effective and easy to scale-up diagnostics to identify causes of HMB and guide treatment, and identifying ways to increase acceptability and access to treatments such as the hormonal intrauterine device for women in low-resource settings.

We invite research proposals on HMB based on the clinical definition that focus on:

  1. Biological Mechanisms – Advancing understanding of the fundamental biology of HMB to identify targets for innovative diagnostics and treatments.
  2. Epidemiology and Impact – Assessing disease burden, patterns, and impact on gynecological health and quality of life in women in low-resource settings.
  3. Measurement and Standardization – Developing and validating improved methods for measuring HMB and establishing standardized research protocols to enable consistent and comparable studies across diverse populations and healthcare systems.
  4. Innovative Diagnostics – Proposing new technology or piloting the use of existing technology to identify causes of HMB in low resource settings, including the use of artificial intelligence. Technology should be easy to use and affordable.
  5. Treatment and Access – Evaluating the effectiveness, acceptability, and ways to increase access to treatment including hormonal contraceptives, to inform patient-centered care in low-resource settings.

Funding Level

We will consider proposals for awards of up to 150,000 USD for each project, with a grant term of up to 2 years. Application budgets should be commensurate with the scope of work proposed. Indirect costs will be considered and should be included in the budget for a maximum of 15% of the total award (subject to the Gates Foundation’s indirect cost policy).

Eligibility Criteria

This initiative is open to nonprofit organizations, for-profit companies, international organizations, government agencies and academic institutions. We particularly encourage applications involving projects led by women or from women-led organizations and applications from institutions based in low- and middle-income countries.

We seek proposals that:

  1. Focus on original research and development.
  2. Focus on the needs of women in Sub-Saharan Africa, India, and Pakistan. While researchers may be based globally, study populations (for original data collection) or intended beneficiaries (for new diagnostics and treatments) must be from these regions.
  3. Address one or more of the outlined objectives within a single proposal.

We will not fund proposals that:

  1. Do not focus on HMB – Even if related to gynecological conditions that are associated with HMB, such as infertility or pelvic pain.
  2. Are not research. Proposals to fund the expansion of routine services, or train clinical service providers, for example, will not be funded. For more information and to apply on or before March 25, go to: https://submit.gatesfoundation.org/prog/accelerating_innovations_to_address_heavy_menstrual_bleeding_in_women_in_low-resource_settings/

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Grants

Government of Canada: Call for concept notes – Health, education and women’s and girls’ rights and empowerment.

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We are currently accepting concept notes. This call has a 2-stage application process. The submission of a concept note is the first stage of a two-stage application process. To be considered for funding:

follow all instructions carefully

use the Partners@International portal https://www.international.gc.ca/world-monde/funding-financement/partners_international-partenaires_international.aspx?lang=eng). submit your application by or before 12 pm (noon) EST April 2, 2025.

diversity. All initiatives supported through this call must ensure the inclusion of women in the delivery of the services and activities, and that women and girls are included as direct beneficiaries.

Within the scope of the three programming areas specified above, projects that align with the  Women’s Voice and Leadership Program will be eligible for consideration under this call. For more information on the program, please see Appendix A. Projects that contribute to Canada’s 10-Year Commitment to Global Health and Rights are also eligible for consideration under this call. Projects must avoid legitimizing the Taliban de facto authorities in any way. Canada will not support projects that invest in or strengthen the Taliban de facto authorities’ ability or capacity to implement systems and institutions that are not inclusive, do not respect human rights, and/or that do not align with widely accepted standards for the principled delivery of international assistance. While it is acceptable to coordinate activities with relevant de facto authorities to facilitate implementation, funding must not directly support de facto ministries or their institutions. This includes avoiding capacity building or technical assistance efforts that risk strengthening systems and advancing policies that do not respect human rights for all. Some capacity building activities would be considered acceptable at the service delivery level if they minimize this risk.  For example, directly training teachers or healthcare workers so that they can deliver quality services to all Afghans in line with international standards, would be considered. In contrast, activities that build the capacity of the de facto authorities to implement Taliban policy and provide oversight to service delivery in the education and health sectors, would not be considered. It is up to the applicant to explain how any proposed support aligns to this principle, and to include this in their risk assessment. For more information, go to: https://www.international.gc.ca/world-monde/funding-financement/empowerment-afghanistan-autonomisation.aspx?lang=eng.

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UNESCO-International Grant for Research in the Life Sciences

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In a perpetually changing world, science is essential for addressing the most urgent challenges, such as emerging diseases, epidemics, pandemics, biodiversity loss, diminishing natural resources, food security, climate change, and natural disasters. The sciences, particularly the life sciences, play a crucial role in helping societies achieve global objectives and propose sustainable solutions. By supporting scientific advances in these fields, we can not only improve the quality of life but also secure a more resilient and equitable future for all.

 UNESCO-Equatorial Guinea Prize

The Prize, funded by the Republic of Equatorial Guinea, is given annually to a maximum of three laureates. They receive a monetary award of USD 300,000 divided equally among laureates, to help further their research, together with a certificate and the “Integracion Tribal” statuette by Equatorial Guinean artist Leandro Mbomio.

The Prize was established by UNESCO’s Executive Board, to support the achievement of the 2030 Agenda for Sustainable Development as well as UNESCO’s global priorities.

The Prize is awarded annually to eminent scientists or groups of scientists, institutions, and non-governmental organisations from numerous fields, such as medicine, biology, agriculture, environmental sciences, and new technologies, who have significantly contributed to improving the quality of life for individuals and communities through outstanding and transformative discoveries. These advancements include medical innovations that extend and enhance patient lives, agricultural techniques that increase crop productivity and sustainability, and environmental research that promotes ecosystem conservation and combats climate change. Additionally, new technologies continue to revolutionise our daily lives by providing innovative and sustainable solutions to global challenges. For more information and to apply before March 31, go to: https://www.unesco.org/en/prizes/equatorial-guinea#apply

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6000GBP Youth Empowerment Grant

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Convenigs offer strong chances for joint efforts that enhance movements, create new links, and motivate collaborations. The Youth Climate Convening Grant aids young activists focused on climate and social justice in developing environments to form connections, think creatively, and get ready for future strength. This grant facilitates the arrangement of events—whether virtual or facetoface—that assist in aligning strategies and achieving common goals.

Eligibility Criteria

We invite applications from youth groups and leaders who meet the following criteria:

  • Age: Applicants must be between 16 and 33 years old.
  • Focus Areas: Actively working on climate and intersectional climate & social justice issues.
  • Geography:
    • This is a global funding opportunity.
    • We particularly encourage applications from the Global South and communities facing greater challenges.
    • Please note: This opportunity is not open to applicants based in India.
  • Type of Applicant: We welcome applications from:
    • Individuals
    • Informal groups
    • Registered organisations

Program Details

  • Grant Amount:
    • The grants range from GBP 500 to GBP 6,000.
  • Program Support:
    • Capacity-building: Skills training, workshops, mentoring, and coaching.
    • Community & Network Building: Learning, sharing best practices, and co-creating collective action.
    • Networking: Relationship building among organisations with similar objectives.
    • Partnerships: Opportunities for creating collaborations.
    • Strategy Development: Developing a collective strategy for addressing specific climate and social justice issues.
    • Resilience & Well-being: Activities that support mental, emotional, and physical well-being, especially for frontline activists and marginalised communities.
  • Logistics Support: The grant can also cover logistical expenses, such as:
    • Travel to convenings (within-country or regionally).
    • Venue hire, catering, sound equipment.
    • Facilitator fees.
  • What We Will Not Fund:
    • Attendance at global events such as COPStockholm50G7/20Climate Weeks, etc. For information and to apply, go to: https://docs.google.com/document/d/1KJIlgvrTt_5KVjmMYogo72mOdUT8zIf7mmoBI0MaVms/edit?usp=drivesdk
    • Prepare Your Application:
      • Description of how the grant will be spent and the activities you plan to carry out.
      • A detailed budget breakdown (template provided).
      • Contact details (either for you as an individual or your organisation).
      • Links to your work (e.g., social media or webpages showcasing your previous initiatives).
    • Application Process:
      • Fill out the application form in the link above.
      • You will be contacted for clarifications or additional information if needed during the selection process.
  1. Grant Management:
    • If your application is approved, we will assist you with managing the grant.
    • You will need to keep receipts for expenses and submit a final report on your activities and the outcomes.
    • We encourage you to share photos or videos of your activities.

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